Analysis of time sequence of glucocorticoid action of granulomatous inflammation.

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Abstract
Time course of the effects of a single local injection of glucocorticoid, hydrocortisone acetate, on the synthesis of collagen, non-collagen protein and DNA, and on vascular permeability of pre-formed carrageenan granuloma in the rat was studied. Maximum inhibitions for the synthetic activity of collagen and non-collagen protein were attained at 4 h after the administration of a single dose (3 mg/kg) of hydrocortisone acetate. The synthetic activity of collagen had recovered quickly to the control level at around 18 h after the injection of the steroid, while non-collagen protein showed a recovery reaching the control level at 32 h. The inhibitory effect of the steroid on the synthetic activity of DNA was greater than those on proteins and a significant inhibition was still noted at 32 h (34.7% inhibition). Vascular permeability measured with the aid of radioiodinated human serum albumin was also inhibited markedly by the steroid treatment and preserved the level of 48% inhibition continuously from 8 h up to the end of the experimental period. Possible differences in the mechanism of action of anti-inflammatory steroid between a single acute and repeated chronic treatments are discussed.

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