Capillary Supercritical Fluid Chromatography of Labile Carboxylic Acids

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Abstract
Free carboxylic acids and prostaglandins were chromato-graphed on well-deactivated capillary columns using supercritical carbon dioxide as mobile phase. A polar cyanopropyl polysiloxane stationary phase provided better solubility of these polar solutes, and gave better peak shapes than conventional nonpolar phases. Thermally labile unsaturated carboxylic acids can be analyzed at low temperatures using capillary supercritical fluid chromatography without losses due to thermal decomposition. Universal detection is afforded by the use of the flame ionization detector.