Gadolinium-labeled dendrimers as biometric nanoprobes to detect vascular permeability
- 5 June 2003
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of Materials Chemistry
- Vol. 13 (7) , 1523-1525
- https://doi.org/10.1039/b304147f
Abstract
PAMAM dendrimer-based biometric nanoprobes G4-1B4M-Gd, G6-1B4M-Gd and G8-1B4M-Gd were used to detect vascular permeability in SCCVII mice tumors. Based on the whole body clearance curve, G8-1B4M-Gd emerged as the ideal candidate for vascular permeability imaging studies due to its stable signal enhancement in the tumor over time. A 2D MR image of a SCCVII tumor showed vessel enhancement without obvious diffuse enhancement.Keywords
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