Influence of Phenothiazines or Reserpine on the Formation of 14C-Glycine from U-14C-Serine

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Abstract
The influence of the psychopharmaceuticals reserpine, thioproperazine and chlorpromazine on the synthesis of 14C-glycine from U-l4C-serine was examined in a rat brain preparation. At low serine concentration (2 • 10^-5 mol/l) glycine synthesis is inhibited by all drugs tested, probably due to the inhibition of the serine influx into mitochondria. At higher concentration (10^-3 mol/l) and physiological cofactor levels, phenothiazines increase to the measurable amount of 14C-glycine while reserpine has no effect. We assume that at this higher concentration serine transport through the mitochondrial membranes is no longer rate limiting; following phenothiazine action, the membrane-bound glycine cleavage system might be inhibited more strongly than the partly soluble serine hydroxymethyltransferase.

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