Patterns of Brain Activity Associated With Variation in Voluntary Wheel-Running Behavior.
- 1 January 2003
- journal article
- Published by American Psychological Association (APA) in Behavioral Neuroscience
- Vol. 117 (6) , 1243-1256
- https://doi.org/10.1037/0735-7044.117.6.1243
Abstract
Rodents spontaneously run on wheels, but what underlies variation within and between species is unknown. This study used Fos immunoreactivity to compare brain activity in mice selectively bred for high wheel running (S) versus control (C) mice. Mice ran for 6 days, but on Day 7, half the mice were prevented from running. A strong positive correlation was found between running distance and Fos in the dentate gyrus of C runners that was lost in S runners. In mice prevented from running, Fos was higher in S than in C in the lateral hypothalamus, medial frontal cortex, and striatum. Results implicate specific brain regions in motivation to run and others in control of the intensity of the locomotor behavior itself.Keywords
This publication has 56 references indexed in Scilit:
- Neural Activation Profile Elicited by Cues Associated with the Anxiogenic Drug Yohimbine Differs from That Observed for Reward-Paired CuesNeuropsychopharmacology, 2002
- Effect of Simple Motor Performance on Regional Dopamine Release in the Striatum in Parkinson Disease Patients and Healthy Subjects: A Positron Emission Tomography StudyJournal of Cerebral Blood Flow & Metabolism, 2002
- Body temperatures of house mice artificially selected for high voluntary wheel-running behavior: repeatability and effect of genetic selectionJournal of Thermal Biology, 2000
- Hippocampal Formation Theta Activity and Movement SelectionNeuroscience & Biobehavioral Reviews, 1998
- Early induction of c-fos precedes increased expression of corticotropin- releasing factor messenger ribonucleic acid in the paraventricular nucleus after immobilization stressEndocrinology, 1992
- Interpreting studies that compare high- and low-selected lines on new charactersBehavior Genetics, 1989
- Expression of c- fos Protein in Brain: Metabolic Mapping at the Cellular LevelScience, 1988
- The contributions of position, direction, and velocity to single unit activity in the hippocampus of freely-moving ratsExperimental Brain Research, 1983
- Relationship between hippocampal theta activity and running speed in the rat.Journal of Comparative and Physiological Psychology, 1975
- Hippocampal activity, behavior, self-stimulation, and heart rate during electrical stimulation of the lateral hypothalamus.Journal of Comparative and Physiological Psychology, 1972