Myocardial potassium uptake with constant arterial potassium concentration.

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Abstract
The role of elevated arterial plasma K concentration upon myocardial K uptake during hypercapnia was studied. PCO2 [CO2 pressure] was increased before and after the infusion of phenoxybenzamine, and myocardial K flux was estimated by multiplying the arteriovenous K difference across the myocardium and the flow in the left anterior descending coronary artery. Phenoxybenzamine temporarily supressed the typical increase in plasma K concentration during hypercapnia. Hypercapnia was associated with a myocardial K uptake both when arterial plasma K increased and when it remained unchanged. The cardiac uptake of observed when arterial K concentration reached its highest level was higher than that seen when arterial K remained at control level. The elevated plasma K concentration of hypercapnia may not be the only cause of myocardial K uptake seen in that situation.

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