THE EFFECTIVENESS OF PHENOBARBITAL IN THE PREVENTION OF RECURRENT FEBRILE CONVULSIONS IN CHILDREN WITH AND WITHOUT A HISTORY OF PRE‐, PERI‐ AND POSTNATAL ABNORMALITIES

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Abstract
Children (300) who had an initial febrile convulsion were divided into 2 groups. In 1 group were children with a single brief generalized initial febrile seizure and no history of pre-, peri- or postnatal abnormalities which might suggest the possibility of brain damage and in the other those with such abnormalities and/or a severe initial febrile convulsion. Daily phenobarbital produced a significant decrease in febrile seizure recurrences in both groups, as compared to those who received phenobarbital at the onset of fever and no phenobarbital prophylaxis. Intermittent phenobarbital given at the onset of fever did not produce a significant difference in recurrence rate as compared with no phenobarbital.