The Involvement of Serotonergic and Dopaminergic Systems in Hypothermia Induced in Mice by Intracerebroventricular Injection of Serotonin

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Abstract
The hypothermia elicited in mice by intracerebroventricular injection (i.c.v.) of serotonin (5-HT) was studied. The 5-HT-induced hypothermia was attenuated by methysergide and pindolol, although ketanserin and p-chlorophenylalanine were without effect. These results suggest that 5-HT-induced hypothermia is produced by the direct activation of the 5-HT1 receptor. In addition, haloperidol, pimozide and .alpha.-MT inhibited 5-HT-induced hypothermia, which indicates that the dopaminergic systems are also involved in 5-HT-induced hypothermia in mice.