Murine DNA repair gene located on chromosome 4
- 1 January 1981
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 289 (5794) , 191-194
- https://doi.org/10.1038/289191a0
Abstract
Somatic cell hybrids between primary mouse embryo fibroblast cells and SV40-transformed human XP (xeroderma pigmentosum) group A cells can express wild-type levels of DNA repair function. These hybrid cells segregate murine chromosomes in culture. The proportion of cells in a given hybrid cell line which can perform unscheduled DNA synthesis (UDS) correlated well with the percentage of the population retaining murine chromosome 4. This is the 1st example of a direct quantitative comparison of specific gene activity and chromosomal content on a cellular basis. [Xeroderma pigmentosum (XP) is an autosomal recessive human disease in which affected individuals are prone to develop skin cancers after exposure to sunlight.].This publication has 16 references indexed in Scilit:
- HUMAN DISORDERS SHOWING INCREASED SENSITIVITY TO THE INDUCTION OF GENETIC DAMAGEAnnual Review of Genetics, 1978
- Repair deficient human disorders and cancerNature, 1978
- Specific action of T4 endonuclease V on damaged DNA in xeroderma pigmentosum cells in vivo.Proceedings of the National Academy of Sciences, 1977
- Changing capacity for DNA excision repair in mouse embryonic cells in vitroExperimental Cell Research, 1977
- XERODERMA PIGMENTOSUM: BIOCHEMICAL AND GENETIC CHARACTERISTICSAnnual Review of Genetics, 1975
- Restoration of ultraviolet-induced unscheduled DNA synthesis of xeroderma pigmentosum cells by the concomitant treatment with bacteriophage T4 endonuclease V and HVJ (Sendai virus).Proceedings of the National Academy of Sciences, 1975
- Ouabain as a selective agent in the isolation of somatic cell hybridsCytogenetic and Genome Research, 1975
- Unscheduled DNA synthesis in hen erythrocyte nuclei reactivated in heterokaryonsExperimental Cell Research, 1972
- The Role of DNA Repair in Aging of Cultured Fibroblasts from Xeroderma Pigmentosum and NormalsExperimental Biology and Medicine, 1971
- Loss of T-antigen from somatic hybrids between mouse cells and SV40-transformed human cells.Proceedings of the National Academy of Sciences, 1968