Influence of LSD-25 on optically evoked potentials in the nonanesthetized rabbit
- 1 June 1959
- journal article
- research article
- Published by American Physiological Society in American Journal of Physiology-Legacy Content
- Vol. 196 (6) , 1181-1184
- https://doi.org/10.1152/ajplegacy.1959.196.6.1181
Abstract
The influence of LSD-25 (i.v.) upon the optically evoked cortical potentials was studied in chronically prepared unanesthetized and noncurarized rabbits over a 23-hour period. With moderate doses of the drug (35 µg/animal) the potentials were enhanced for a period of over 6 hours. The time course of the amplitudes indicates a triphasic pattern. LSD-25 reduced the latency of the potentials by about 10%. LSD-25 was found to have a marked effect upon variability of both the amplitude and the latency. Both these variabilities were greatly reduced for 1–3 hours after injection.Keywords
This publication has 1 reference indexed in Scilit:
- Some Effects of Lysergic Acid Diethylamide and Bufotenine on Electrical Activity in the Cat's Visual SystemAmerican Journal of Physiology-Legacy Content, 1955