UPTAKE OF AGGREGATED IMMUNOGLOBULIN BY THE MOUSE KIDNEY .1. EFFECT OF ENDOTOXIN
- 1 January 1980
- journal article
- research article
- Vol. 61 (1) , 22-29
Abstract
[Escherichia coli] endotoxin (ET) pre-treatment of mice resulted in increased liver and spleen uptake and decreased circulating levels of aggregated Ig[immunoglobulin]G (AggIgG) compared to control animals. ET had no effect upon the uptake of AggIgG by lung or whole kidney cortex. Immunofluorescent microscopy revealed increased localization of AggIgG in the mesangium of ET mice at 1 but not at 2 or 16 h after administration of AggIgG. Mesangial macromolecular uptake is not solely dependent upon blood levels but may be influenced by unknown and probably complex variables.This publication has 19 references indexed in Scilit:
- Glomerular localization of aggregated protein in mice; effect of strain difference and relationship to systemic macrophage function.1975
- Effect of Cortisone on the Disappearance Kinetics and Tissue Localization of Soluble Immune ComplexesThe Journal of Immunology, 1975
- EFFECT OF MANIPULATION OF RETICULOENDOTHELIAL SYSTEM ACTIVITY ON GLOMERULAR DEPOSITION OF AGGREGATED PROTEIN AND IMMUNE-COMPLEXES IN 2 DIFFERENT STRAINS OF MICE1975
- Saturation of the Reticuloendothelial System with Soluble Immune ComplexesThe Journal of Immunology, 1974
- The glomerular mesangium. II. Studies of macromolecular uptake in nephrotoxic nephritis in rats.Journal of Clinical Investigation, 1974
- The glomerular mesangiumJournal of Clinical Investigation, 1972
- Increased mitotic activity in rabbit endothelium after endotoxin. An autoradiographic study.1971
- Evidence concerning the origin of liver macrophages.1971
- The ultrastructure of the juxtaglomerular apparatus as disclosed by three-dimensional reconstructions from serial sectionsJournal of Ultrastructure Research, 1970
- GLOMERULAR LOCALIZATION AND TRANSPORT OF AGGREGATED PROTEINS IN MICE1967