PHARMACOKINETICS OF HIGH-DOSE IV ALIZAPRIDE IN PREVENTION OF CISPLATIN-INDUCED EMESIS

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Abstract
Alizapride is a new antidopaminergic-related benzamide with specific antiemetic properties. Pharmacokinetics at a high repetitive dose (16 mg/kg) shows a biexponential plasma decay with T1/2.alpha. of 8.33 .+-. 2.47 min and T1/2.beta. 2.8 .+-. 0.7 hr. Large Vdss and high total body clearance are apparent. We demonstrate an increase in drug exposure during the first 6 hr after CDDP infusion by shortening the interval between injections. We conclude that the rate of infusion of alizapride could be important in the efficacy of the drug.