ROLE OF DOPAMINE IN THE DIURESIS CAUSED BY STIMULATION OF ATRIAL RECEPTORS

Abstract
The diuretic response to stimulation of left atrial receptors, by distending balloons located either at the pulmonary vein-left atrial junctions or in the body of the left atrium was studied during blockade of dopamine receptors using a continuous infusion of sulpiride in doses ranging from 0.632-5.153 .mu.mol/kg per min, in anesthetized dogs. A diuretic response was obtained in each experiment of distension of the balloons: the response was similar to that observed in dogs without blockade of dopamine receptors and was not significantly related to the dose of sulpiride used. Apparently, the diuretic response to stimulation of atrial receptors, known to be mediated by a blood-borne agent, is unlikely to be caused by dopamine.

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