Cyclophosphamide Treatment of Experimental Allergic Encephalomyelitis in Lewis Rats

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Abstract
Cyclophosphamide (CY) treatment (daily doses of 5 or 8 mg/kg for 10 days or less) of Lewis rats with paralytic experimental allergic encephalomyelitis (EAE) results in clinical remission and reversal of histologic evidence of disease in a high proportion of animals. Continued administration of CY is required to maintain these beneficial effects. CY treatment diminishes but does not abolish cutaneous reactivity to tuberculoprotein in Lewis rats sensitized to mycobacteria. On the basis of these and other observations, CY is believed to exert therapeutic effects in EAE by inhibiting proliferation of inflammatory cells and release of injurious factors within the sites of EAE lesions in brain and spinal cord.

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