Symptom Profiles in Chronic Peptic Ulcer Disease

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Abstract
Abdominal and mental symptoms were assessed in 103 outpatients with chronic peptic ulcer disease. Patients with present symptoms and a history of duodenal or prepyloric ulcer were included if they had no other disorder requiring treatment. A normal female population was used for comparison of mental symptoms. Besides the cardinal ulcer or acid-related symptoms, there was a high rate of indigestion and bowel dysfunction symptoms, usually associated with the irritable bowel syndrome. Mental symptoms were reported by almost all patients. Symptoms of anxiety, depression and neurasthenia were seen significantly more often among the female patients than in the normal women. A wide range of both abdominal and mental symptoms should apparently be taken into account in the therapeutic management of peptic ulcer disease, evaluation of clinical trials and studies of the normal history.

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