Improved Cerebral Resuscitation From Cardiac Arrest in Dogs With Mild Hypothermia Plus Blood Flow Promotion

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Abstract
Background and Purpose In past studies, cerebral outcome after normothermic cardiac arrest of 10 or 12.5 minutes in dogs was improved but not normalized by resuscitative (postarrest) treatment with either mild hypothermia or hypertension plus hemodilution. We hypothesized that a multifaceted combination treatment would achieve complete cerebral recovery. Methods With our established dog outcome model, normothermic ventricular fibrillation of 11 minutes (without blood flow) was followed by controlled reperfusion (with brief normothermic cardiopulmonary bypass simulating low flow and low Pao2 of external cardiopulmonary resuscitation) and defibrillation at <2 minutes. Controlled ventilation was provided to 20 hours and intensive care to 96 hours. Control group 1 (n=8) was kept normothermic (37.5°C), normotensive, and hypocapnic throughout. Experimental group 2 (n=8) received mild resuscitative hypothermia (34°C) from about 10 minutes to 12 hours (by external and peritoneal cooling) plus cerebral blood flow ...