Sequential expression in the nervous system of C-MYB andVIP genes, located in human chromosomal region 6q24

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Abstract
Vasoactive intestinal peptide (VIP) is a major neuropeptide involved in multiple functions such as vasodilation, smooth-muscle relaxation, sweat secretion, gastrointestinal peristalsis, pancreatic function, and brain activity. In view of the multiple roles associated with VIP,it is important to understand its gene regulation. We have recently isolated the human VIPgene and determined its structure. By in situ hybridization techniques we have now localized this gene to the long arm of chromosome 6, 6q24, a chromosomal region that has been shown previously to contain the coding sequences for the nuclear protooncogene c-myb.Genes found in close proximity to each other on the chromosome are often functionally related and, as VIPis primarily expressed in the nervous system, we investigated the possible correlation of c-mybto VIPin neuronal tissue. A sharp peak of c-mybmRNA was observed in the hippocampus of 3-day-old rats, preceding the peak of VIPmRNA that occurs in this brain area at 8 days of age. Thus, the protooncogene c-mybmay be associated with events in brain development occurring prior to the appearance of elevated concentrations of VIP.