STUDIES ON SUPRARENAL INSUFFICIENCY

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Abstract
In suprarenalectomized rats previous thyroidectomy does not alter the symptoms or the mortality %, or the increased susceptibility to diphtheria toxin and to histamine poisoning. Intraperitoneal injections of 6-10 cc. of a 5% solution of glucose may cause death. Normal rats do not show any ill effects after such injections. Daily injections of 10 cc. of glucose solution do not influence the increased susceptibility to histamine poisoning. Such injections apparently do not influence the increased susceptibility to diphtheria toxin. It is suggested that in rats dehydration is not an important factor in subacute and chronic suprarenal insufficiency and the attendant increased susceptibility to intoxication.

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