Similarity of Hematologic Effect of Pyridoxine Deficiency, Cortisone, and Myeloid Metaplasia Factor of Human Urine.

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Abstract
Similar hematologic and histologic changes occurred in mice treated with cortisone, in mice made pyridoxine deficient, and in mice treated with a myeloid metaplasia factor from human urine. These changes consisted of granulocytosis in the peripheral blood and myeloid metaplasia in the spleen. In addition, cortisone treatment and pyridoxine deficiency caused lymphopenia. The changes produced by pyridoxine deficiency and by the urine fractions are not necessarily mediated through the mechanism of the alarm reaction. The hematopoietic results of cortisone admn. may be the result of the establishment of an effective deficiency of the active vit. B6 coenzyme, occurring at some stage in the metabolic cycle with which the vit. is concerned.

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