Adenylate Kinase Activity in Mycobacterium leprae

Abstract
Adenylate kinase (ATP:AMP phsophotransferase, EC 2.7.4.3) was detected in partially purified preparations of cell-free extracts of Mycobacterium leprae. The apparent Km values of M. leprae adenylate kinase for ADP and Mg2+ were 1 .times. 10-4 M and 4 .times. 10-4 M, respectively. The enzyme was heat-liable: loss of activity by 80% at 45.degree. C and over 90% at 60.degree. C occurred within 5 min. M. leprae adenylate kinase was distinct from armadillo adenylate kinase in respect of affinity for substrate and heat-sensitivity.