SYNTHESIS AND ASSEMBLY OF IMMUNOGLOBULINS BY MALIGNANT HUMAN PLASMACYTES
Open Access
- 1 July 1970
- journal article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 132 (1) , 148-162
- https://doi.org/10.1084/jem.132.1.148
Abstract
Three basic patterns of γ-globulin synthesis are described in malignant human plasmacytes: extreme unbalanced synthesis where only L chains are synthesized; unbalanced synthesis in which intact γG globulin and an excess of free L chains are synthesized and secreted; and balanced synthesis where H and L chains appear to be synthesized in equimolar amounts. Studies of the cellular products appear to reflect the biosynthetic processes of the cells in a more reliable fashion than does analysis of serum or urinary proteins.Keywords
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