CORRECTION OF CONGENITAL DIAPHRAGMATIC-HERNIA IN UTERO .1. THE MODEL - INTRA-THORACIC BALLOON PRODUCES FATAL PULMONARY HYPOPLASIA
- 1 January 1980
- journal article
- research article
- Vol. 88 (1) , 174-182
Abstract
A conical silicone rubber balloon was placed in the left hemithorax of fetal lambs and progressively inflated through an exteriorized catheter over the last trimester. Newborn lambs died of severe respiratory insufficiency, despite maximal resuscitation. The lungs were markedly hypoplastic with greatly reduced parenchymal mass and air capacity. This model of a progressively enlarging intrathoracic mass which produces severe pulmonary hypoplasia and fatal respiratory insufficiency simulates the pathophysiology of congenital diaphragmatic hernia in human neonates.This publication has 3 references indexed in Scilit:
- Morphologic analysis of the pulmonary vascular bed in congenital left-sided diaphragmatic herniaThe Journal of Pediatrics, 1978
- The lung following repair of congenital diaphragmatic herniaThe Journal of Pediatrics, 1977
- Unsuspected Pulmonary Vascular Abnormalities Associated With Diaphragmatic HerniaPediatrics, 1976