Erythema gyratum repens. A case studied with immunofluorescence, immunoelectron microscopy and immunohistochemistry
- 1 July 1994
- journal article
- Published by Oxford University Press (OUP) in British Journal of Dermatology
- Vol. 131 (1) , 102-107
- https://doi.org/10.1111/j.1365-2133.1994.tb08465.x
Abstract
We report a patient with erythema gyratum repens (EGR), in whom a bronchial carcinoma was found. Direct immunofluorescence revealed granular deposits of immunoglobulins at the basement membrane zone (BMZ) in the skin, and in the lung tumour. Direct immunoelectron microscopy showed that the immune deposits were localized just beneath the lamina densa. Indirect immuno- fluorescence revealed circulating anti-BMZ antibodies. Immunohistochemical staining, using anti- transforming growth factor-β, anti-epidermal growth factor receptor, antivimentin and anti-α-actin, was found to be more intense in the lesional skin and the lung tumour than in normal tissues. Possible mechanisms in the pathogenesis of EGR are discussed.Keywords
This publication has 27 references indexed in Scilit:
- Erythema gyratum repens: Direct immunofluorescence microscopic findingsJournal of the American Academy of Dermatology, 1993
- Cutaneous markers of internal malignancy. II. Paraneoplastic dermatoses and environmental carcinogensJournal of the American Academy of Dermatology, 1993
- Erythema gyratum repens: A paraneoplastic eruptionJournal of the American Academy of Dermatology, 1992
- Erythema gyratum repens in a healthy womanJournal of the American Academy of Dermatology, 1992
- Immunogold Staining of Intermediate-Sized Filaments of the Vimentin Type in Human Skin: A Postembedding Immunoelectron Microscopic StudyJournal of Investigative Dermatology, 1990
- Recurrent thrombosis and anticardiolipin antibodies associated with adenocarcinoma of the lungPublished by Oxford University Press (OUP) ,1990
- A mechanism of peripheral spread or localization of inflammatory reactions — Role of the localized ground substance adaptive phenomenonMedical Hypotheses, 1989
- The Biology of Cachectin/TNF -- A Primary Mediator of the Host ResponseAnnual Review of Immunology, 1989
- Melanoma, Growth Factors, Acanthosis Nigricans, the Sign of Leser-Trélat, and Multiple AcrochordonsNew England Journal of Medicine, 1987
- Erythema gyratum repens and undifferentiated carcinomaArchives of Dermatology, 1967