Characterization of binding site of closed-state KCNQ1 potassium channel by homology modeling, molecular docking, and pharmacophore identification
- 8 July 2005
- journal article
- Published by Elsevier in Biochemical and Biophysical Research Communications
- Vol. 332 (3) , 677-687
- https://doi.org/10.1016/j.bbrc.2005.04.165
Abstract
No abstract availableKeywords
This publication has 22 references indexed in Scilit:
- Mutation of colocalized residues of the pore helix and transmembrane segments S5 and S6 disrupt deactivation and modify inactivation of KCNQ1 K+ channelsThe Journal of Physiology, 2005
- Blockers of the Slowly Delayed Rectifier Potassium IKs Channel: Potential Antiarrhythmic AgentsCurrent Medicinal Chemistry-Cardiovascular & Hematological Agents, 2003
- Molecular Determinants of KCNQ1 Channel Block by a BenzodiazepineMolecular Pharmacology, 2003
- Chemistry of ion coordination and hydration revealed by a K+ channel–Fab complex at 2.0 Å resolutionNature, 2001
- Design and Synthesis of 4-Substituted Benzamides as Potent, Selective, and Orally Bioavailable IKs BlockersJournal of Medicinal Chemistry, 2001
- The cardiac K+ channel KCNQ1 is essential for gastric acid secretionGastroenterology, 2001
- IKs, a Slow and Intriguing Cardiac K+ Channel and Its Associated Long QT DiseasesTrends in Cardiovascular Medicine, 1998
- Class III Antiarrhythmic Activity in Vivo by Selective Blockade of the Slowly Activating Cardiac Delayed Rectifier Potassium Current IKs by (R)-2-(2,4- Trifluoromethyl)-N-[2-oxo-5-phenyl- 1-(2,2,2-trifluoroethyl)-2,3-dihydro- 1H-benzo[e][1,4]diazepin-3-yl]acetamideJournal of Medicinal Chemistry, 1997
- [20] VERIFY3D: Assessment of protein models with three-dimensional profilesPublished by Elsevier ,1997
- AQUA and PROCHECK-NMR: Programs for checking the quality of protein structures solved by NMRJournal of Biomolecular NMR, 1996