Gastrointestinal Toxicity With Celecoxib vs Nonsteroidal Anti-inflammatory Drugs for Osteoarthritis and Rheumatoid Arthritis
Top Cited Papers
Open Access
- 13 September 2000
- journal article
- clinical trial
- Published by American Medical Association (AMA) in JAMA
- Vol. 284 (10) , 1247-1255
- https://doi.org/10.1001/jama.284.10.1247
Abstract
For patients with musculoskeletal disorders, conventional nonsteroidal anti-inflammatory drugs (NSAIDs) are a mainstay of clinical care.1-3 Well-established limitations of NSAID therapy, however, include the risk of developing significant injury to the upper gastrointestinal (GI) tract.4-10 The annualized incidence rate of symptomatic GI ulcers and ulcer complications in NSAID users ranges from 2% to 4% (1%-2% for ulcer complications alone).11-15 NSAID-related ulcer complications are estimated to lead to 107,000 hospitalizations and 16,500 deaths yearly in the United States.10Keywords
This publication has 1 reference indexed in Scilit:
- Nonsteroidal Anti-inflammatory Drug Use and Increased Risk for Peptic Ulcer Disease in Elderly PersonsAnnals of Internal Medicine, 1991