Antigenicity of Monocomponent Porcine Insulin in Rabbits
- 1 January 1974
- journal article
- research article
- Published by Georg Thieme Verlag KG in Hormone and Metabolic Research
- Vol. 6 (03) , 175-177
- https://doi.org/10.1055/s-0028-1093866
Abstract
Monocomponent and commercial porcine insulin preparations administered with Freund's adjuvant, induced insulin antibodies in rabbits. The results show that the proinsulin-like contaminants in commercial insulin are not the essential stimuli for insulin antibody formation, and that purification of insulin per se is not sufficient to render insulin non-immunogenic. The physical state of insulin is more important in its immunogenicity.Keywords
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