Dental Caries in the Syrian Hamster

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Abstract
The effect of 3 fluoride compounds of different solubility on dental caries in hamsters was studied on the hypothesis that the post-eruptive caries-inhibiting effect of the fluorides might be related to the availability of the F ion. An attempt was also made to obtain information on a post-eruptive systemic effect from fluoride admd. parenterally. 50 ppm. of F, as NaF added to food and water, was very effective in reducing caries activity in the molar teeth of hamsters; Na fluorosilicate was somewhat less effective; and CaF2 was essentially ineffective. Hamsters do not appear to be well suited for studying the post-eruptive systemic pathways of fluoride action on caries activity due to contamination of the oral cavity with urine and feces.

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