AUTOANTIBODIES AND SPLEEN CELL-MEDIATED CYTOTOXICITY IN ADRIAMYCIN-INDUCED MYOCARDIOPATHY IN RABBITS

  • 1 January 1976
    • journal article
    • research article
    • Vol. 36  (4) , 1462-1469
Abstract
Spleen cells from rabbits affected by adriamycin (an antitumor drug) induced cardiomyopathy were specifically cytotoxic for rabbit embryonic heart cells in microcytotoxicity tests. The interactions between sensitized spleen cells and rabbit embryonic heart cells were observed by scanning electron microscopy. Sera from these rabbits were shown by immunofluorescence to contain antibodies reactive with rabbit embryonic heart, kidney and muscle cells. Cytotoxic antibodies were not detected. These sera contained factors that enhanced the cytotoxicity mediated by sensitized spleen cells and made normal spleen cells capable of destroying targets. The detection of these factors and of cytotoxins was dependent on the method of target-effector cells treatment by serum.

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