The Anxiolytic But Not the Sedative Properties of Tracazolate Are Reversed by the Benzodiazepine Receptor Antagonist, Ro 15-1788

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Abstract
The effects of the novel putative anxiolytic, tracazolate, were investigated in the social interaction of anxiety and the holeboard. Tracazolate (5 mg/kg) had an anxiolytic action that was no longer observed at higher doses (10–25 mg/kg); in the holeboard tracazolate produced a dose-related (5–25 mg/kg) depression of exploratory head-dipping, locomotor activity and rearing. The effects of tracazolate in the social interaction test, but not in the holeboard, could be reversed by the benzodiazepine receptor antagonist, Ro 15–1788 (10 mg/kg).