Virus Inhibitory Activity of Polyvinylamine.

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Abstract
A comparative study of the virus inhibitory efficacy of the synthetic basic polypeptide, polylysine, and the synthetic basic polymer, polyvinylamine, revealed that both polymers inhibited the production of influenza B virus in the chick embryo. Polyvinylamine had a sparing effect on chick embryos infected with Newcastle disease virus and as little as 40mug inhibited the multiplication of mumps virus. A comparison with the results of previous studies with polylysine revealed that the polypeptide was more effective than polyvinylamine as a virus inhibitor. It appears probable that the essential feature of this type of virus inhibitor is that it be a basic poly-electrolyte and that a polypeptide backbone may not be essential for activity.

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