Role of the galactose lectin of Entamoeba histolytica in adherence-dependent killing of mammalian cells
- 1 December 1991
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 59 (12) , 4681-3
- https://doi.org/10.1128/iai.59.12.4681-4683.1991
Abstract
Entamoeba histolytica extracellular killing of host cells is contact dependent. Adherence to human colonic epithelial cells and mucins is mediated by a galactose-specific lectin. The effect on cytotoxicity of a panel of monoclonal antibodies (MAb) directed against the galactose lectin was tested. As expected, those MAb which inhibited adherence also decreased cytotoxicity. However, one antilectin MAb blocked cytotoxicity after adherence had occurred, indicating that the lectin has a role in cell killing that is distinct from its adherence function.Keywords
This publication has 13 references indexed in Scilit:
- Sequence of a cysteine-rich galactose-specific lectin of Entamoeba histolytica.Proceedings of the National Academy of Sciences, 1991
- Primary structure of the 170-kDa surface lectin of pathogenic Entamoeba histolytica.Proceedings of the National Academy of Sciences, 1991
- Entamoeba histolytica: Recognition of α- and β-galactose by the 260-kDa adherence lectinExperimental Parasitology, 1991
- Association of Serum Antibodies to Adherence Lectin with Invasive Amebiasis and Asymptomatic Infection with Pathogenic Entamoeba histolyticaThe Journal of Infectious Diseases, 1990
- Monoclonal antibodies directed against the galactose-binding lectin of Entamoeba histolytica enhance adherence.The Journal of Immunology, 1990
- Subunit structure of the galactose and N-acetyl-D-galactosamine-inhibitable adherence lectin of Entamoeba histolyticaJournal of Biological Chemistry, 1989
- Isolation of the galactose-binding lectin that mediates the in vitro adherence of Entamoeba histolytica.Journal of Clinical Investigation, 1987
- Acid Intracellular Vesicles and the Cytolysis of Mammalian Target Cells by Entamoeba histolytica Trophozoites1The Journal of Protozoology, 1986
- Role of Adherence in Cytopathogenic Mechanisms of Entamoeba HistolyticaJournal of Clinical Investigation, 1981
- Cytopathogenic mechanisms of Entamoeba histolytica.The Journal of Experimental Medicine, 1980