Haemoglobin E Variants and Pregnancy in Malaysian Aborigines

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Abstract
Haemoglobin E complicates 22.2% of pregnancy in Malaysian aborigines, the prevalence of variants E associated with pregnancy being, 15.8% with Hb E trait abnormality, 3.9% with Hb E homozygous disease, and 2.5% with Hb E thalassaemia disease. Minor haematological abnormalities occur with the trait and homozygous conditions, though a more unfavourable response is expected with Hb E thalassaemia. Haemolysis is not a prominent feature and it is suggested that factors other than the haemoglobinopathic state probably accounts for any unfavourable response in pregnancy.

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