Comparative study of bacampicillin and ampicillin in the treatment of uncomplicated gonorrhoea.

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Abstract
Bacampicillin hydrochloride, a pro-drug ester of ampicillin trihydrate which is hydrolysed to ampicillin after absorption, was used in a randomized comparative study of ampicillin (3.5 g) and bacampicillin (1.6 g) (each with probenecid 1 g) in the treatment of uncomplicated gonorrhea. This dose of bacampicillin was selected because in serum it gives approximately the same peak concentration of ampicillin as 3.5 g of the parent drug. Genital, pharyngeal and anal cultures were performed at the initial visit and at follow up 5-9 days after treatment. There was no statistically significant difference in the microbiological or clinical response of patients with genital gonorrhea who were treated with ampicillin and those treated with bacampicillin. At 5-9 days after treatment, 93% of the ampicillin-treated patients and 89% of the bacampicillin-treated patients had negative genital, pharyngeal and anal culture results; 87% and 89%, respectively, had no symptoms of infection. Fewer gastrointestinal side effects were noted in the patients treated with bacampicillin.