PHARMACOKINETICS AND PHARMACODYNAMICS OF MEPINDOLOL SULFATE

  • 1 January 1980
    • journal article
    • research article
    • Vol. 18  (4) , 169-176
Abstract
Five clinically healthy, male volunteers were each given an i.v. dose 1.19 mg 2-methyl-14C-mepindolol sulphate, followed 1 wk later by an oral dose of 20 mg. The effect of mepindolol sulphate was studied in 3 male test subjects after repeated oral administration for 8 days with a daily dose of 2 .times. 2.5 mg using the heart rate behavior model during submaximum ergometer exercise. Synchronously with pharmacodynamics, pharmacokinetic data were obtained after multiple dosing.