Regulation of toxocariasis in mice selectively reared for high and low immune responses to Nematospiroides dubius

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Abstract
Test mice have been selectively reared for high (H) or low (L) immune responses to Nematospiroides dubius. After secondary infection with N. dubius, the L mice voided ten times as many eggs in their faeces as the II mice, and at necropsy, 71% versus 20% of the inoculum of N. dubius were recovered as adult worms from the L and II mice respectively. Furthermore, N. dubius were more fecund in the L than in H mice. High or low immune responsiveness was not restricted to N. dubius infection in these mice but was also observed during Toxocara canis infection. The migration of T canis larvae from gut via the liver to skeletal muscle and CNS was inhibited in H versus L mice. Many more larvae were recovered from the livers of II compared with L mice which was indicative of greater immunity in the H mice. The protective immune response in H compared with L mice to both N. dubius and T canis included pronounced cosinophilia and elevated antiparasite antibody titres.

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