An inherited defect in granulocyte function: impaired chemotaxis, phagocytosis and intracellular killing of microorganisms.

  • 1 April 1976
    • journal article
    • case report
    • Vol. 30  (6) , 537-41
Abstract
The neutrophil granulocytes of a 1-year-old boy with severe recurrent infections were found to have almost no chemotactic responsiveness, impaired phagocytosis and reduced intracellular killing of Candida albicans "in vitro". During the course of a febrile illness of unknown etiology which was accompanied by a leukemoid reaction, phagocytic activity became normal; the chemotactic response was also increased but still remained slightly subnormal. Family studies suggested that the defect was an inherited autosomal recessive one.

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