Effect of Low Zinc Intake on Absorption and Excretion of Zinc by Infants Studied with 70Zn as Extrinsic Tag

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Abstract
The effect of low dietary intake of zinc was studied in six normal infants with the use of 70Zn as an extrinsic tag. Of the two study formulas, one provided a zinc intake similar to that of customary infant formulas (“high” intake), whereas the other provided a “low” zinc intake. Two zinc absorption studies were performed with each formula (sequence: high-low-low-high). Extrinsically labeled formula was fed for 24 h and excreta were collected for 72 h. Zinc isotope ratios were determined by inductively coupled plasma mass spectrometry (ICP/MS). When zinc intake was high, net zinc absorption was 9.1 ± 8.7% (mean ± SD) of intake and net zinc retention was 74 ± 91 µg/(kg · d). True zinc (70Zn) absorption was 16.8 ± 5.8% of intake and fecal excretion of endogenous zinc was 78 ± 56 µg/(kg · d). When zinc intake was low, net absorption of zinc increased significantly (P < 0.001) to 26.0 ± 13.0% of intake, but net retention was not significantly different at 42 ± 33 µg/(kg · d). True absorption of zinc also increased significantly (P < 0.001) to 41.1 ± 7.8% of intake, whereas fecal endogenous zinc decreased (P < 0.05) to 34 ± 16 µg/(kg · d) during low zinc intake. Thus, infants maintain zinc balance in the face of low zinc intake through increased efficiency of absorption and decreased excretion of endogenous zinc.