CSF characteristics in early-onset multiple sclerosis
- 23 November 2004
- journal article
- research article
- Published by Wolters Kluwer Health in Neurology
- Vol. 63 (10) , 1966-1967
- https://doi.org/10.1212/01.wnl.0000144352.67102.bc
Abstract
The authors studied CSF characteristics in 136 patients with multiple sclerosis (MS) with a disease onset before age 16. In the initial diagnostic lumbar puncture, CSF-pleocytosis was observed in 66%, blood–CSF barrier dysfunction in 13%, and oligoclonal IgG in 92% of the early-onset MS (EOMS) patients. CSF oligoclonal IgG supports the early diagnosis of MS in childhood with a sensitivity similar to adult-onset MS.Keywords
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