Regulation of Cholesterol Catabolism by Bile Salts and Glycyrrhetic Acid in vivo.
- 1 October 1965
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 120 (1) , 6-8
- https://doi.org/10.3181/00379727-120-30427
Abstract
Summary Tritiated cholesterol was injected intraperitoneally into rats having 2 bile-duct cannulae, one for bile collection and the other for intraduodenal infusion of bile-salt solutions. Intraduodenal infusion of taurocholate (10 mg/hr) had no effect on rates of radioactive bile-salt formation from cholesterol-H3. Intraduodenal infusion of taurochenodeoxycholate (10 mg/hr) inhibited radioactive bile salt formation. Taurocholate infusion also resulted in a 6-fold increased secretion of a dihydroxycholanate, apparently taurochenodeoxycholate. Sodium β-glycyr-rhetate infusion (125 μg/hr) had no significant effect on secretion of either radioactive cholesterol or radioactive bile salts.This publication has 4 references indexed in Scilit:
- THE EFFECT OF BILE SALTS AND SOME BILE-SALT ANALOGUES ON THE OXIDATION OF CHOLESTEROL BY LIVER MITOCHONDRIABiochemical Journal, 1963
- The Fate of Tritium-Labelled β-Glycyrrhetic Acid in the RatJournal of Pharmacy and Pharmacology, 1963
- The determination of di- and trihydroxycholanic acids in bileAnalytical Biochemistry, 1961
- Regulation of Cholesterol Oxidation by Liver in vitro.Experimental Biology and Medicine, 1959