Ischemic Preconditioning: From Adenosine Receptor to KATP Channel
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- 1 March 2000
- journal article
- review article
- Published by Annual Reviews in Annual Review of Physiology
- Vol. 62 (1) , 79-109
- https://doi.org/10.1146/annurev.physiol.62.1.79
Abstract
▪ Abstract Ischemic preconditioning is a phenomenon whereby exposure of the myocardium to a brief episode of ischemia and reperfusion markedly reduces tissue necrosis induced by a subsequent prolonged ischemia. It is hoped that elucidation of the mechanism for preconditioning will yield therapeutic strategies capable of reducing myocardial infarction. In the rabbit, the brief period of preconditioning ischemia and reperfusion releases adenosine, bradykinin, opioids, and oxygen radicals. The combined effect of the release of these substances on G proteins and the cell’s phospholipases induces the translocation and activation of the ε isozyme of protein kinase C. Protein kinase C appears to be the first element of a complex kinase cascade that is activated during the prolonged ischemia in preconditioned hearts. Current evidence indicates that this cascade contains at least one tyrosine kinase and ultimately leads to the activation of p38 mitogen-activated protein kinase. p38 Mitogen-activated protein kinase...Keywords
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