Effect of Substituents on the Retention in HPLC Chromatography of Strychnine Derivatives

Abstract
The capacity factork, relative retentions αSP and log αSP values measured on μPorasil columns for 33 strychnine derivatives using CHCl3:MeOH (containing ca 2% NH4OH) (93:7) as eluent in normal-phase chromatography. The results allow for the estimation of the effect of various substituents on the retention of these alkaloids.