Comparative effects of biological therapies on the severity of skin symptoms and health-related quality of life in patients with plaque-type psoriasis: a meta-analysis

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Abstract
Background: The comparative effects of biological response modifiers (BRMs) on the severity of psoriasis and its effects on health-related quality of life (HRQoL) have not been evaluated.Objective: To conduct a meta-analysis to assess the effects of available biological agents on the severity of psoriasis, as well as to provide data on the effects of these agents on HRQoL.Methods: Medline and other databases were searched for randomized controlled trials (≥ 10 weeks’ duration in adults) comparing biological therapies for moderate-to-severe psoriasis with placebo. A Mantel–Haenszel fixed-effects model was employed to estimate the pooled relative risks (RR) of patients achieving ≥ 75% reduction of baseline Psoriasis Area and Severity Index (PASI 75) after ≥ 10 weeks of treatment. Similar analyses were also conducted on PASI 50 and PASI 90. Using a random-effects model, we estimated the likelihood of achieving PASI 50, PASI 75, and PASI 90 at 10–12 weeks and 24 weeks. Data on the effects of different...