Subcellular Distribution of Aromatase in Human Placenta and Ovary
- 1 January 1979
- journal article
- research article
- Published by S. Karger AG in Hormone Research
- Vol. 11 (4) , 179-185
- https://doi.org/10.1159/000179053
Abstract
The aromatization of androstenedione in human ovarian microsomes is inhibited by an antibody to porcine hepatic microsomal NADPH-cytochrome c reductase. Likewise, the antibody inhibits aromatization in mitochondria isolated from human ovaries and placentae. A given quantity of the antibody produces the same percent inhibition of aromatization in microsomes and mitochondria of both ovaries and placentae. These data, in addition to the low specific activity observed for the mitochondrial aromatase, indicate that aromatization in mitochondria probably results from microsomal contamination.Keywords
This publication has 1 reference indexed in Scilit:
- Partial resolution of the placental microsomal aromatase complexJournal of Steroid Biochemistry, 1976