Electrolyte composition of experimental galactose cataracts

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Abstract
The composition of galactose-induced cataractous lens differs from that of the normal rat lens. Weight is decreased due to loss of both water and organic solids. Within a few days of maturation of the cataracts the sodium and calcium concentrations are increased and potassium is virtually absent from the lens. No differences were found in the water content or electrolyte composition of other nonvascular tissues such as tendon, cornea or cartilage in rats maintained on a high galactose intake as compared to the control group of rats on a glucose diet. Modifications of the diet by the inclusion of sulfasuxidine or by sulfasuxide plus low calcium do not modify the general electrolyte pattern of the cataractous lens. In rats ingesting a high galactose, calcium-deficient diet cataracts develop sooner than in the presence of adequate dietary calcium.

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