No association of polymorphisms of the CTLA-4 exon 1(+ 49) and promoter(- 318) genes with rheumatoid arthritis in the Korean population
- 1 January 2002
- journal article
- research article
- Published by Taylor & Francis in Scandinavian Journal of Rheumatology
- Vol. 31 (5) , 266-270
- https://doi.org/10.1080/030097402760375142
Abstract
The aim of this study is to investigate the significance of the polymorphisms of the cytotoxic T lymphocyte associated antigen-4 (CTLA-4) exon 1(+ 49) and promoter(- 318) genes in rheumatoid arthritis (RA). Polymerase chain reaction of genomic DNA-restriction fragment length polymorphism was used to determine genotypes of the CTLA-4 exon 1(+ 49) and promoter(- 318) in 86 RA patients and 86 healthy control subjects. There was no significant difference in genotype, allele and phenotype frequencies of the CTLA-4 exon 1(+ 49) and promoter(- 318) genes between RA patients and control subjects. There was no significant difference in age at onset, severity, functional class ( S 3), physician global assessment, ESR, CRP or RF titer in patients with RA according to the CTLA-4 polymorphisms. Our data show that the polymorphisms within the CTLA-4 exon 1(+ 49) and promoter(- 318) genes are not associated with susceptibility to RA and its clinical/serological manifestations in the Korean population.Keywords
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