Syntheses of Curcumin Bioconjugates and Study of Their Antibacterial Activities against β-Lactamase-Producing Microorganisms
- 15 June 2001
- journal article
- research article
- Published by American Chemical Society (ACS) in Bioconjugate Chemistry
- Vol. 12 (4) , 464-469
- https://doi.org/10.1021/bc0000482
Abstract
In the present study curcumin bioconjugates, viz. di-O-glycinoylcurcumin (I), di-O-glycinoyl-C4-glycylcurcumin (II), 5‘-deoxy-5‘-curcuminylthymidine (5‘-cur-T) (IV), and 2‘-deoxy-2‘-curcuminyluridine (2‘-cur-U) (V) have been synthesized and characterized by elemental analysis and 1H NMR. The turmeric peptide (Tp) was isolated from the aqueous turmeric extract of the turmeric rhizome. The antibacterial activity of these four bioconjugates and also of the turmeric peptide and sodium salt of curcumin (III) have been tested particularly for β-lactamase-producing microorganisms.Keywords
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