Inhibition of the cataleptic effect of tetrahydrocannabinol by other constituents of Cannabis sativa L.
- 1 February 1988
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 40 (2) , 132-134
- https://doi.org/10.1111/j.2042-7158.1988.tb05198.x
Abstract
Tetrahydrocannabinol (THC) induced catalepsy in mice, whereas a cannabis oil (6.68% w/w THC), four cannabinoids and a synthetic mixture did not. Cannabinol (CBN) and olivetol inhibited THC-induced catalepsy in the mornings and the evenings, but cannabidiol (CBD) exhibited this effect only in the evenings. A combination of CBN and CBD inhibited THC-induced catalepsy equal to that of CBN alone in the mornings, but this inhibition was greater than that produced by CBN alone in the evenings.This publication has 7 references indexed in Scilit:
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