Lowering the perinatal mortality and the prematurity rate; the value of prophylactic thiazides in juveniles

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Abstract
The incidence of toxemia and rates of perinatal mortality and prematurity were compared in 1,340 normal juveniles who received thiazides prophylactically with 1, 743 normal juveniles who did not receive thiazides. More than a 10% increase in arterial pressure and albuminuria not due to infection developed in 61 (5%) of the treated patients and 270 (15%) of the nontreated patients. In the 1,340 treated patients the perinatal mortality was 0.7% (one stillbirth plus eight neonatal deaths) and the prematurity rate was 5% (73 infants). In the 1, 743 nontreated patients the perinatal mortality was 5% (53 stillbirths plus 11 neonatal deaths) and the prematurity rate was 12% (223 infants). It is concluded that the prophylactic use of thiazides not only protects the mother from toxemia but also significantly reduces perinatal mortality and prematurity.