Elemental fluorine : Part 16. Versatile thin-film gas–liquid multi-channel microreactors for effective scale-out
- 6 January 2005
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Lab on a Chip
- Vol. 5 (2) , 191-198
- https://doi.org/10.1039/b416400h
Abstract
Versatile and conveniently operated microreactor devices, suitable for long term chemical synthesis for both laboratory and industrial use, are described. Direct fluorination of ethyl acetoacetate by fluorine gas is used as a model reaction to illustrate the successful application of reactors having either 9, 18 or 30 microchannels, with all channels supplied from single reagent sources, to provide significant quantities of fluorinated products. Convenient reactor maintenance, simple design, versatility and the enhanced safety features of using such modular microreactor devices, make these systems appropriate for synthesis on the large scale.Keywords
This publication has 16 references indexed in Scilit:
- Fluorine in Organic ChemistryPublished by Wiley ,2004
- Elemental fluorine: Part 15. Selective direct fluorination of quinoline derivativesJournal of Fluorine Chemistry, 2004
- Elemental fluorineLab on a Chip, 2001
- The application of micro reactors to synthetic chemistryChemical Communications, 2001
- Microreactors, a new efficient tool for optimum reactor designChemical Engineering Science, 2001
- Microreaction engineering — is small better?Chemical Engineering Science, 2001
- Chemical and biochemical microreactorsTrAC Trends in Analytical Chemistry, 2000
- State-of-the-art in microreaction technology: concepts, manufacturing and applicationsElectrochimica Acta, 1999
- Microreactors for elemental fluorineChemical Communications, 1999
- Electrophilic NF Fluorinating AgentsChemical Reviews, 1996