Paullones are potent inhibitors of glycogen synthase kinase‐3β and cyclin‐dependent kinase 5/p25
Open Access
- 1 October 2000
- journal article
- research article
- Published by Wiley in European Journal of Biochemistry
- Vol. 267 (19) , 5983-5994
- https://doi.org/10.1046/j.1432-1327.2000.01673.x
Abstract
Paullones constitute a new family of benzazepinones with promising antitumoral properties. They were recently described as potent, ATP-competitive, inhibitors of the cell cycle regulating cyclin-depe...Keywords
This publication has 93 references indexed in Scilit:
- Identification of the 23 kDa subunit of tau protein kinase II as a putative activator of cdk5 in bovine brainPublished by Wiley ,2001
- A New Molecular Link between the Fibrillar and Granulovacuolar Lesions of Alzheimer's DiseaseThe American Journal of Pathology, 1999
- Phosphorylation of tau protein by recombinant GSK‐3β: pronounced phosphorylation at select Ser/Thr‐Pro motifs but no phosphorylation at Ser262 in the repeat domainFEBS Letters, 1999
- PresenilinsMolecular Neurobiology, 1999
- Mechanisms of cyclin-dependent kinase regulation: structures of cdks, their cyclin activators, and cip and INK4 inhibitorsJournal of Molecular Biology, 1999
- Lithium inhibits Alzheimer's disease‐like tau protein phosphorylation in neuronsFEBS Letters, 1997
- Phosphorylation of τ Protein by Casein Kinase‐1 Converts It to an Abnormal Alzheimer‐Like StateJournal of Neurochemistry, 1995
- Potent Inhibition of Cdc2 Kinase Activity by the Flavonoid L86-8275Biochemical and Biophysical Research Communications, 1994
- A cdc2‐related kinase PSSALRE/cdk5 is homologous with the 30 kDa subunit of tau protein kinase II, a proline‐directed protein kinase associated with microtubuleFEBS Letters, 1993
- Purification of tau, a microtubule-associated protein that induces assembly of microtubules from purified tubulinJournal of Molecular Biology, 1977